We argue that explanationist views in epistemology continue to face persistent challenges to both their necessity and their sufficiency. This is so despite arguments offered by Kevin McCain in a paper recently published in this journal which attempt to show otherwise. We highlight ways in which McCain’s attempted solutions to problems we had previously raised go awry, while also presenting a novel challenge for all contemporary explanationist views.

Augustine on select metaphysical topics: hylomorphism vs. dualism, theories of God, angels.

This article expands our knowledge of the historical-philosophical process by which the dominant metaphysical account of the Christian God became ascendant. It demonstrates that Marius Victorinus proposed a peculiar model of ‘consubstantiality’ that utilised a notion of ‘existence’ indebted to the Aristotelian concept of ‘prime matter’. Victorinus employed this to argue that God is a unity composed of Father and Son. The article critically evaluates this model. It then argues that Augustine noticed one of the model's philosophical liabilities but did (...) not publicly name Victorinus when he rejected it in De Trinitate, thereby exemplifying the practice of private ‘rebuke’ (ἐλέγχɛιν). (shrink)

This chapter is a work in applied metaphysics. Recent discussions of monism and metaphysical dependence are deployed to develop a view—the doctrine of divine priority (DDP)—that is a viable alternative to the doctrine of divine simplicity (DDS). DDS and the traditional motivation for it are discussed, then DDP is introduced by way of an analogy involving Jonathan Schaffer’s distinction between two forms of monism. It is argued that DDP is an alternative to DDS by showing that it is consistent with (...) the traditional motivation for the latter view, and argued that DDP is a viable alternative by showing that objections to its peculiar implications rest on assumptions that can reasonably be rejected. In the concluding section, the findings of the main discussion are summarized and DDP’s potential theological import is illustrated with a brief discussion of a possible solution to the Problem of the Trinity it affords. (shrink)

What can contemporary machine learning (ML) models do? Given the proliferation of ML models in society, answering this question matters to a variety of stakeholders, both public and private. The evaluation of models' capabilities is rapidly emerging as a key subfield of modern ML, buoyed by regulatory attention and government grants. Despite this, the notion of an ML model possessing a capability has not been interrogated: what are we saying when we say that a model is able to do something? (...) And what sorts of evidence bear upon this question? -/- In this paper, we aim to answer these questions, using the capabilities of large language models (LLMs) as a running example. Drawing on the large philosophical literature on abilities, we develop an account of ML models' capabilities which can be usefully applied to the nascent science of model evaluation. Our core proposal is a conditional analysis of model abilities (CAMA): crudely, a machine learning model has a capability to X just when it would reliably succeed at doing X if it 'tried'. The main contribution of the paper is making this proposal precise in the context of ML, resulting in an operationalisation of CAMA applicable to LLMs. We then put CAMA to work, showing that it can help make sense of various features of ML model evaluation practice, as well as suggest procedures for performing fair inter-model comparisons. (shrink)

This paper presents and defends a model of religious faith as an epistemic disposition. According to the model, religious faith is a disposition to take certain doxastic attitudes toward propositions of religious significance upon entertaining certain mental states. Three distinct advantages of the model are advanced. First, the model allows for religious faith to explain the presence and epistemic appropriateness of religious belief. Second, the model accommodates a variety of historically significant perspectives concerning the relationships between faith and evidence, faith (...) and volition, and faith and doubt. And, finally, the model offers an appealing account of what unifies religious faith with other kinds of faith. (shrink)

It is not uncommon to think that the existence of exhaustive and infallible divine foreknowledge uniquely threatens the existence of human freedom. This paper shows that this cannot be so. For, to uniquely threaten human freedom, infallible divine foreknowledge would have to make an essential contribution to an explanation for why our actions are not up to us. And infallible divine foreknowledge cannot do this. There remains, however, an important question about the compatibility of freedom and foreknowledge. It is a (...) question not about the existence of foreknowledge, but about its mechanics. (shrink)

Descriptive accounts of the nature of explanation in neuroscience and the global goals of such explanation have recently proliferated in the philosophy of neuroscience and with them new understandings of the experimental practices of neuroscientists have emerged. In this paper, I consider two models of such practices; one that takes them to be reductive; another that takes them to be integrative. I investigate those areas of the neuroscience of learning and memory from which the examples used to substantiate these models (...) are culled, and argue that the multiplicity of experimental protocols used in these research areas presents specific challenges for both models. In my view, these challenges have been overlooked largely because philosophers have hitherto failed to pay sufficient attention to fundamental features of experimental practice. I demonstrate that when we do pay attention to such features, evidence for reduction and integrative unity in neuroscience is simply not borne out. I end by suggesting some new directions for the philosophy of neuroscience that pertain to taking a closer look at the nature of neuroscientific experiments. (shrink)

Augustine’s accounts of his so-called mystical experiences in conf. 7.10.16, 17.23, and 9.10.24 are puzzling. The primary problem is that, although in all three accounts he claims to have seen “that which is,” we have no satisfactory account of what “that which is” is supposed to be. I shall be arguing that, contrary to a common interpretation, Augustine’s intellectual “seeing” of “being” in Books 7 and 9 was not a vision of the Christian God as a whole, nor of one (...) of the divine persons, each of whom is equally God, according to Augustine. This becomes clear when we attend to the fact that Augustine is appropriating a specific meaning of “that which is” or “being” used by Plotinus in his account of the lover of Beauty. This resolution, however, leads to a second question. Is there anything distinctively Christian about any, or all, of Augustine’s ascents? On the one hand, it would be odd if there were not, given that the Confessions are addressed to the Christian God. On the other hand, upon close inspection we find that the allegedly specific “Christian” characteristics that modern commentators have identified in the ascents of conf. 7 and 9 also occur in the Neoplatonists. I will argue that there is in fact one important difference between Augustine and the Neoplatonists here that has not been pointed out in these prior interpretations. (shrink)

Seneca asserts in Letter 121 that we mature by exercising self-care as we pass through successive psychosomatic “constitutions.” These are babyhood (infantia), childhood (pueritia), adolescence (adulescentia), and young adulthood (iuventus). The self-care described by Seneca is 'self-affiliation' (oikeiōsis, conciliatio) the linchpin of the Stoic ethical system, which defines living well as living in harmony with nature, posits that altruism develops from self-interest, and allows that pleasure and pain are indicators of well-being while denying that happiness consists in pleasure and that (...) pain is misery. Augustine divides the narrative of his own development into the stages of babyhood (infantia), childhood (pueritia), adolescence (adulescentia), and young adulthood (iuventus) in the Confessions, a text wherein he claims familiarity with more than a few works of Seneca (Conf. 5.6.11). Furthermore, he had access to Stoic accounts of affiliation not only in Seneca’s Letter 121, but also in Cicero’s On Goals, and in non-extant sources of Stoic ethical theory. After pointing out that Augustine endorsed the notion of self-affiliation outside of the Confessions, I raise the question of whether he also makes the notion of affiliation thematic in his philosophical autobiography. I argue that he does indeed present himself and some of his primary relationships – with his mother and his long-term girlfriend – in terms of personal and social oikeiōsis. In addition, his self-critiques in the early books of the Confessions can be more fully understood if compared to Stoic developmental theory. He depicts himself as failing to progress intellectually, socially, and morally: although he passed through the successive constitutions, becoming physically larger and cognitively capable, he did not mature correctly by the standards of his Stoic sources. (shrink)

Against those who dismiss Kant's project in the "Religion" because it provides a Pelagian understanding of salvation, this paper offers an analysis of the deep structure of Kant's views on divine justice and grace showing them not to conflict with an authentically Christian understanding of these concepts. The first part of the paper argues that Kant's analysis of these concepts helps us to understand the necessary conditions of the Christian understanding of grace: unfolding them uncovers intrinsic relations holding between God's (...) justice and grace. Parts two and three provide an analysis of two concepts of grace used by Kant. Getting clear on their differences is the key to understanding why Kant's account is not Pelagian. (shrink)

G.E.M. Anscombe famously claimed that ‘the Hebrew-Christian ethic’ differs from consequentialist theories in its ability to ground the claim that killing the innocent is intrinsically wrong. According to Anscombe, this is owing to its legal character, rooted in the divine decrees of the Torah. Divine decrees confer a particular moral sense of ‘ought’ by which this and other act-types can be ‘wrong’ regardless of their consequences, she maintained. There is, of course, a potentially devastating counter-example. Within the Torah, Abraham is (...) apparently commanded by God to slaughter and set fire to his innocent son, Isaac. For attempting to do so, he is praised in the Biblical passage and by later Jewish and Christian commentators. This paper examines rabbinic and early Christian analyses of the story and finds that it was not unambiguously held by these interpreters that God absolutely prohibits killing the innocent, until the time of Augustine, whose position on the story evolved over time. (shrink)

Some scholars suggest that John Locke’s revisions to the chapter “Of Power” for the 1694 second edition of his Essay concerning Human Understanding may be indebted to the Cambridge Platonist, Ralph Cudworth. Their claims rest on evidence that Locke may have had access to Cudworth’s unpublished manuscript treatises on free will. In this paper, I examine an alternative suggestion – the claim that Cudworth’s daughter, Damaris Cudworth Masham, and not Cudworth himself, may have exerted an influence on Locke’s revisions. I (...) discuss the plausibility of this claim in light of the relevant historical and textual evidence. (shrink)

The past decade has witnessed a growing awareness of conceptual and methodological hurdles within psychology and neuroscience that must be addressed for taxonomic and explanatory progress in understanding psychological functions to be possible. In this paper, I evaluate several recent knowledge-building initiatives aimed at overcoming these obstacles. I argue that while each initiative offers important insights about how to facilitate taxonomic and explanatory progress in psychology and neuroscience, only a “coordinated pluralism” that incorporates positive aspects of each initiative will have (...) the potential for success. (shrink)

Despite its centrality in the philosophy of cognitive science, there has been little prior philosophical work engaging with the notion of representation in contemporary NLP practice. This paper attempts to fill that lacuna: drawing on ideas from cognitive science, I introduce a framework for evaluating the representational claims made about components of neural NLP models, proposing three criteria with which to evaluate whether a component of a model represents a property and operationalising these criteria using probing classifiers, a popular analysis (...) technique in NLP (and deep learning more broadly). The project of operationalising a philosophically-informed notion of representation should be of interest to both philosophers of science and NLP practitioners. It affords philosophers a novel testing-ground for claims about the nature of representation, and helps NLPers organise the large literature on probing experiments, suggesting novel avenues for empirical research. (shrink)

In a recent letter, Dillion et. al (2023) make various suggestions regarding the idea of artificially intelligent systems, such as large language models, replacing human subjects in empirical moral psychology. We argue that human subjects are in various ways indispensable.

Writing to the young emperor Nero, Seneca elaborates a sophisticated distinction between compassion and mercy for use in forensic contexts, agreeing with earlier Stoics that compassion is a vice, but adding that there is a virtue called mercy or 'clemency.' This Stoic repudiation of compassion has won the attention of Nussbaum, who argues that it was motivated by a respect for persons as dignified agents, and was of a piece with the Stoics' cosmopolitanism. This chapter engages Nussbaum's presentation of the (...) Stoics, examining Seneca’s On Clemency and Epictetus' use of the term prohairesis, showing that while there is some truth in her characterization, it needs to be qualified in important ways. It also analyzes Augustine's engagement with Seneca's On Clemency in the City of God 9.5, and in his letters concerning punishment for vandalism, theft, and human trafficking. It argues that Augustine has a nuanced mercy ethic that is deeply informed by Seneca's position, but that he intentionally improves upon it. (shrink)

Before her death in 1673, Margaret Cavendish, the Duchess of Newcastle, expressed a wish that her philosophical work would experience a ‘glorious resurrection’ in future ages. During her lifetime, and for almost three centuries afterwards, her writings were destined to ‘lye still in the soft and easie Bed of Oblivion’. But more recently, Cavendish has received a measure of the fame she so desired. She is celebrated by feminists, literary theorists, and historians. There are regular conferences organised by the International (...) Margaret Cavendish Society, and there have been several biographies, as well as essay collections, journal issues, scholarly editions, and anthologies devoted to her work. In terms of studies in the history and philosophy of science, however, Cavendish has yet to achieve her resurrection in full. While there have been journal articles and book chapters, and a 2001 edition of her Observations, there have been (until now) no book-length studies of her philosophy, and there is currently no modern edition of her other major work, the Philosophical Letters. This essay-length review of Lisa Sarasohn’s The Natural Philosophy of Margaret Cavendish highlights why Cavendish should still hold interest for philosophers today. (shrink)

Against the backdrop of the English reception of Locke’s Essay, stands a little-known philosophical dispute between two seventeenth-century women writers: Mary Astell (1666-1731) and Damaris Cudworth Masham (1659-1708). On the basis of their brief but heated exchange, Astell and Masham are typically regarded as philosophical adversaries: Astell a disciple of the occasionalist John Norris, and Masham a devout Lockean. In this paper, I argue that although there are many respects in which Astell and Masham are radically opposed, the two women (...) also have a surprising amount in common. Rather than interpret their ideas solely in relation to the ‘canonical’ philosophies of the time – Lockean empiricism and Malebranchean occasionalism – I examine the ways in which Astell and Masham are influenced by the metaphysical theories of the Cambridge Platonists, Ralph Cudworth and Henry More. On this basis, I argue that a remarkably similar theological approach underlies the metaphysical and feminist arguments of Astell and Masham. (shrink)

In her Remarks Upon Some Writers (1743), Catharine Trotter Cockburn takes a seemingly radical stance by asserting that it is possible for atheists to be virtuous. In this paper, I examine whether or not Cockburn’s views concerning atheism commit her to a naturalistic ethics and a so-called radical enlightenment position on the independence of morality and religion. First, I examine her response to William Warburton’s critique of Pierre Bayle’s arguments concerning the possibility of a society of virtuous atheists. I argue (...) that this response shows Cockburn vacillating between a moral naturalism, on the one hand, and a theistic morality, on the other. Second, I draw on Cockburn’s letters to her niece Ann Arbuthnot, and her opinions concerning mystical ideas about “the will of God” in north-east Scotland in the mid-eighteenth century. I maintain that these letters give us a fuller appreciation of Cockburn’s naturalistic position. My conclusion is that Cockburn’s ideas concerning atheism prompt us to consider the close interplay between secular and religious principles in so-called radical ideas of the period. (shrink)

Many pantheists have claimed that their view of the divine is motivated by a kind of spiritual experience. In this paper, I articulate a novel argument, inspired by recent work on moral exemplarism, that gives voice to this kind of motivation for pantheism. The argument is based on two claims about the emotion of awe, each of which is defended primarily via critical engagement with empirical research on the emotion. I also illustrate how this pathway to pantheism offers pantheists distinctive (...) resources for responding to persistent objections to their view, and how it might lead to more exotic views incorporating pantheistic elements. (shrink)

In this chapter I investigate the kinds of changes that psychiatric kinds undergo when they become explanatory targets of areas of sciences that are not “mature” and are in the early stages of discovering mechanisms. The two areas of science that are the targets of my analysis are cognitive neuroscience and cognitive neurobiology.

The Morris water maze has been put forward in the philosophy of neuroscience as an example of an experimental arrangement that may be used to delineate the cognitive faculty of spatial memory (e.g., Craver and Darden, Theory and method in the neurosciences, University of Pittsburgh Press, Pittsburgh, 2001; Craver, Explaining the brain: Mechanisms and the mosaic unity of neuroscience, Oxford University Press, Oxford, 2007). However, in the experimental and review literature on the water maze throughout the history of its use, (...) we encounter numerous responses to the question of “what” phenomenon it circumscribes ranging from cognitive functions (e.g., “spatial learning”, “spatial navigation”), to representational changes (e.g., “cognitive map formation”) to terms that appear to refer exclusively to observable changes in behavior (e.g., “water maze performance”). To date philosophical analyses of the water maze have not been directed at sorting out what phenomenon the device delineates nor the sources of the different answers to the question of what. I undertake both of these tasks in this paper. I begin with an analysis of Morris’s first published research study using the water maze and demonstrate that he emerged from it with an experimental learning paradigm that at best circumscribed a discrete set of observable changes in behavior. However, it delineated neither a discrete set of representational changes nor a discrete cognitive function. I cite this in combination with a reductionist-oriented research agenda in cellular and molecular neurobiology dating back to the 1980s as two sources of the lack of consistency across the history of the experimental and review literature as to what is under study in the water maze. (shrink)

This paper offers a critique of an account of explanatory integration that claims that explanations of cognitive capacities by functional analyses and mechanistic explanations can be seamlessly integrated. It is shown that achieving such explanatory integration requires that the terms designating cognitive capacities in the two forms of explanation are stable but that experimental practice in the mind-brain sciences currently is not directed at achieving such stability. A positive proposal for changing experimental practice so as to promote such stability is (...) put forward and its implications for explanatory integration are briefly considered. (shrink)

This paper explores Kant's concept of the highest good and the postulate of the existence of God arising from it. Kant has two concepts of the highest good standing in tension with one another, an immanent and a transcendent one. I provide a systematic exposition of the constituents of both variants and show how Kant’s arguments are prone to confusion through a conflation of both concepts. I argue that once these confusions are sorted out Kant’s claim regarding the need to (...) postulate God’s existence from a moral point of view makes much more sense. (shrink)

Our modern ideals about liberty were forged in the great political and philosophical debates of the 17th and 18th centuries, but we seldom hear about women's contributions to those debates. This paper examines the ideas of early modern English women – namely Margaret Cavendish, Mary Astell, Mary Overton, ‘Eugenia’, Sarah Chapone and the civil war women petitioners – with respect to the classic political concepts of negative, positive and republican liberty. The author suggests that these writers' woman-centred concerns provide a (...) unique historical perspective on these much-discussed ideals of freedom from external interference, freedom as self-determination and freedom from domination. (shrink)

(Updated 5/23/24) This unpublished paper, which readers should feel free to cite, is posted primarily for the historical record. In recent work that has, deservedly, received some attention, Paul R. Daniels presents and defends a non-standard theory of persistence that he dubs transdurantism, according to which persisting objects are temporally extended simples. This is exactly what I do in work dating back to Spring 2004. (This work includes this version of this paper, as well as later version that was presented (...) to the University of Rochester's Philosophy Department in 2005.) While this might be a total coincidence, I doubt that it is, especially given that 'transdurantism' appears as a name for a theory of persistence associated with me in at least two places in the literature, one of which includes a citation of this paper. The paper begins with a discussion of what I call 'locative relations' (the relations borne by material objects to the regions of space and time they occupy), which draws relevant distinctions that others have failed to draw. The results of this discussion are then used in constructing spatial analogues for the three established theories of persistence--endurantism, perdurantism, and exdurantism--as well as for transdurantism. Next, these four views concerning persistence are explicitly formulated and a defense of their formulation is offered. Finally, transdurantism's advantages and disadvantages relative to the other theories are discussed. The main goal of the paper is to challenge the trichotomy between the established theories by arguing that transdurantism is also a viable view concerning persistence through time. [Note: Befitting its status as a historical document, with the exception of some light editing to fix typos that might impede understanding, no changes have been made to the paper.]. (shrink)

In my dissertation, I address a variety of issues in the metaphysics of space and related areas. I begin by discussing the popular thesis that regions of space are identical to sets of points in space. I present three arguments against this thesis and conclude that we should be skeptical of it. In its place, I propose an axiomatic theory of regions of space that is consistent with both reductive accounts of their nature and with accounts that treat them as (...) sui generis entities. -/- I next explore the consequences of the aforementioned considerations. In particular, I describe five different sorts of structure each of which is such that the claim that space could have that structure is consistent with the axiomatic theory previously proposed. I claim that this fact, together with the skepticism concerning reductive accounts argued for earlier, shows that we should take seriously the claim that space could have any of these structures. -/- Having argued that we should be skeptical of the thesis that regions of space are identical to sets of points in space and suggesting that space could have different sorts of structure, I discuss how best to analyze continuity. I present an analysis of continuity inspired by remarks of Richard Cartwright in his 1975 paper ‘Scattered Objects’. I argue that this Cartwrightian analysis should be rejected because it identifies regions of space with sets of points in space, and I present a modified version of the analysis that does not do so. I note, however, that there is an intuitive notion of continuity that is not captured by this modified Cartwrightian analysis. I present and defend an analysis of continuity that better captures this intuitive notion. -/- I then turn to the issue of how to analyze what it is for a region of space to be open and what it is for a region of space to be closed. Here I argue that Cartwright’s analyses of these notions are incorrect. I then present a series of alternative analyses, revising each in response to objections. This process culminates with my proposed analyses of what it is for a region of space to be open and what it is for a region of space to be closed. -/- Finally, I discuss the Maximally Continuous Account of Simples (MaxCon), originally formulated and defended by Ned Markosian in his 1998 paper ‘Simples’. I argue that Markosian’s version of MaxCon, which identifies regions of space with sets of points in space and relies on the Cartwrightian analysis of continuity, should be rejected. I then formulate a new version of MaxCon that builds on the views defended earlier in my dissertation and defend this new version of MaxCon from objections. (shrink)

Efforts by governments, firms, and patients to deliver pioneering drugs for critical health needs face a challenge of diminishing efficiency in developing those medicines. While multi-sectoral collaborations involving firms, researchers, patients, and policymakers are widely recognized as crucial for countering this decline, existing incentives to engage in drug development predominantly target drug manufacturers and thereby do little to stimulate collaborative innovation. In this mini review, we consider the unexplored potential within pharmaceutical regulations to create novel incentives to encourage a diverse (...) set of actors from the public and private spheres to engage in the kind of collaborative knowledge exchange requisite for fostering enhanced innovation in early drug development. (shrink)

In his De la recherche de la vérité (The Search after Truth) of 1674-75, Nicolas Malebranche makes a number of apparently contradictory remarks about women and their capacity for pure intellectual thought. On the one hand, he seems to espouse a negative biological determinism about women’s minds, and on the other, he suggests that women have the free capacity to attain truth and happiness, regardless of their physiology. In the early eighteenth-century, four English women thinkers – Anne Docwra (c. 1624-1710), (...) Mary Astell (1666-1731), Damaris Masham (1659-1708), and Mary Chudleigh (1656-1710) – engaged with Malebranche’s ideas. Their writings reveal how we might dispel the apparent contradictions in Malebranche’s thinking about women, and reaffirm the liberating potential of Cartesian philosophy for women in the early modern period. (shrink)

This paper examines Aristotle's attempt to describe space in terms of place in the Physics, and shows why Aristotle rejected both Platonic and Atomistic understandings of space.

In this article, I explain why stabilizing constructs is important to the success of the Research Domain Criteria Project and identify one measure for facilitating such stability.

In the 1706 third edition of her Reflections upon Marriage, Mary Astell alludes to John Locke’s definition of slavery in her descriptions of marriage. She describes the state of married women as being ‘subject to the inconstant, uncertain, unknown, Arbitrary Will of another Man’ (Locke, Two Treatises, II.22). Recent scholars maintain that Astell does not seriously regard marriage as a form of slavery in the Lockean sense. In this paper, I defend the contrary position: I argue that Astell does seriously (...) regard marriage as a form of slavery for women and that she condemns this state of affairs as morally wrong. I also show that, far from criticizing Locke, Astell draws on key passages in his Thoughts concerning Education to urge that women be educated to retain their liberty. (shrink)

This paper takes stock of Leibnizian influences on Schleiermacher's thought through an examination and comparison of the views of Leibniz, Kant, and Schleiermacher on predication. I analyze each thinker's foundational ontological and epistemological commitments and their implications for their understanding of predication. More specifically, I explore whether Schleiermacher's adoption of Leibiniz' theory of the complete concept and the theory of prediction it entails conflicts with his adoption of Kant's two-source theory of knowledge. I conclude that it does, and that it (...) is this clash between elements borrowed from two very different systematic thinkers that makes Schleiermacher's Dialektik the cipher that it is. (shrink)

In 2007, ten world-renowned neuroscientists proposed “A Decade of the Mind Initiative.” The contention was that, despite the successes of the Decade of the Brain, “a fundamental understanding of how the brain gives rise to the mind [was] still lacking” (2007, 1321). The primary aims of the decade of the mind were “to build on the progress of the recent Decade of the Brain (1990-99)” by focusing on “four broad but intertwined areas” of research, including: healing and protecting, understanding, enriching, (...) and modeling the mind. These four aims were to be the result of “transdisciplinary and multiagency” research spanning “across disparate fields, such as cognitive science, medicine, neuroscience, psychology, mathematics, engineering, and computer science.” The proposal for a decade of the mind prompted many questions (See Spitzer 2008). In this chapter, I address three of them: (1) How do proponents of this new decade conceive of the mind? (2) Why should a decade be devoted to understanding it? (3) What should this decade look like? (shrink)

Optogenetic techniques are described as “revolutionary” for the unprecedented causal control they allow neuroscientists to exert over neural activity in awake behaving animals. In this paper, I demonstrate by means of a case study that optogenetic techniques will only illuminate causal links between the brain and behavior to the extent that their error characteristics are known and, further, that determining these error characteristics requires comparison of optogenetic techniques with techniques having well known error characteristics and consideration of the broader neural (...) and behavioral context in which the targets of optogenetic interventions are situated. (shrink)

Neuroscience is a laboratory-based science that spans multiple levels of analysis from molecular genetics to behavior. At every level of analysis experiments are designed in order to answer empirical questions about phenomena of interest. Understanding the nature and structure of experimentation in neuroscience is fundamental for assessing the quality of the evidence produced by such experiments and the kinds of claims that are warranted by the data. This article provides a general conceptual framework for thinking about evidence and experimentation in (...) neuroscience with a particular focus on two research areas: cognitive neuroscience and cognitive neurobiology. (shrink)

In The Women of Grub Street (1998), Paula McDowell highlighted the fact that the overwhelming majority of women’s texts in early modern England were polemical or religio-political in nature rather than literary in content. Since that time, the study of early modern women’s political ideas has dramatically increased, and there have been a number of recent anthologies, modern editions, and critical analyses of female political writings. As a result of Patricia Springborg’s research, Mary Astell (1668-1731) has risen to prominence as (...) one of the most astute female political commentators of her day. Springborg argues for Astell’s importance as one of the first systematic critics of the philosopher John Locke, and she interprets Astell’s political thought as a reaction to Lockean Whig politics in the early reign of Queen Anne. But some scholars claim that it is a mistake to think that Astell was chiefly preoccupied with Locke, and others suggest that reading Astell in relation to Locke alone can distort our understanding of her larger political theory. In this chapter, I argue that a more accurate picture of Astell’s political outlook emerges by examining a little studied essay, ‘A Prefatory Discourse to Dr D’Aveanant’ in her 1704 work Moderation Truly Stated. In this critique of Charles Davenant’s Essays upon Peace at Home, and War Abroad (1704), Astell provides a commentary on the political ruthlessness of Niccolo Machiavelli in his Discourses on Livy. Astell’s comments reveal that, in an age in which the political vocabulary was turning to the language of rights, property, and liberty, she still subscribed to the ancient world view, and the ethical-political language of virtue and the good. My intention is to show that these ethical dimensions of Astell’s political thought are consonant with her wider philosophy. (shrink)

Do neurobiologists aim to discover natural kinds? I address this question in this chapter via a critical analysis of classification practices operative across the 43-year history of research on long-term potentiation (LTP). I argue that this 43-year history supports the idea that the structure of scientific practice surrounding LTP research has remained an obstacle to the discovery of natural kinds.

What role does the concept of representation play in the contexts of experimentation and explanation in cognitive neurobiology? In this article, a distinction is drawn between minimal and substantive roles for representation. It is argued by appeal to a case study that representation currently plays a role in cognitive neurobiology somewhere in between minimal and substantive and that this is problematic given the ultimate explanatory goals of cognitive neurobiological research. It is suggested that what is needed is for representation to (...) instead play a more substantive role. (shrink)

Many scholars point to the close association between early modern science and the rise of rational arguments in favour of the existence of witches. For some commentators, it is a poor reflection on science that its methods so easily lent themselves to the unjust persecution of innocent men and women. In this paper, I examine a debate about witches between a woman philosopher, Margaret Cavendish , and a fellow of the Royal Society, Joseph Glanvill . I argue that Cavendish is (...) the voice of reason in this exchange—not because she supports the modern-day view that witches do not exist, but because she shows that Glanvill’s arguments about witches betray his own scientific principles. Cavendish’s responses to Glanvill suggest that, when applied consistently, the principles of early modern science could in fact promote a healthy scepticism toward the existence of witches. (shrink)

Hud Hudson has argued that if MaxCon, Ned Markosian's favored answer to the Simple Question, is true, then there couldn't be gunky objects. If Hudson's argument succeeds, then those who believe that gunky objects are possible have a good reason to reject MaxCon. However, I show that Hudson's argument relies on substantive metaphysical claims that a proponent of MaxCon need not accept. Thus, one who endorses MaxCon need not reject the possibility of gunky objects and those who believe that gunky (...) objects are possible need not reject MaxCon. (shrink)

This article investigates several consequences of a recent trend in philosophy of mind to shift the relata of realization from mental state–physical state to function‐mechanism. It is shown, by applying both frameworks to the neuroscientific case study of memory consolidation, that, although this shift can be used to avoid the immediate antireductionist consequences of the traditional argument from multiple realizability, what is gained is a far more modest form of reductionism than recent philosophical accounts have intimated and neuroscientists themselves have (...) claimed. (shrink)

According to some scholars, Mary Astell’s feminist programme is severely limited by its focus on self-improvement rather than wider social change. In response, I highlight the role of ‘virtuous friendship’ in Astell’s 1694 work, A Serious Proposal to the Ladies. Building on classical ideals and traditional Christian principles, Astell promotes the morally transformative power of virtuous friendship among women. By examining the significance of such friendship to Astell’s feminism, we can see that she did in fact aim to bring about (...) reformation of society and not just the individual. (shrink)

In this chapter, I argue that scientific practice in the neurosciences of cognition is not conducive to the discovery of natural kinds of cognitive capacities. The “neurosciences of cognition” include cognitive neuroscience and cognitive neurobiology, two research areas that aim to understand how the brain gives rise to cognition and behavior. Some philosophers of neuroscience have claimed that explanatory progress in these research areas ultimately will result in the discovery of the underlying mechanisms of cognitive capacities. Once such mechanistic understanding (...) is achieved, cognitive capacities purportedly will be relegated into natural kind categories that correspond to real divisions in the causal structure of the world. I provide reasons here, however, in support of the claim that the neurosciences of cognition currently are not on a trajectory for discovering natural kinds. As I explain, this has to do with how mechanistic explanations of cognitive capacities are developed. Mechanistic explanations and the kinds they explain are abstract representational byproducts of the conceptual, experimental and integrative practices of neuroscientists. If these practices are not coordinated towards developing mechanistic explanations that mirror the causal structure of the world, then natural kinds of cognitive capacities will not be discovered. I provide reasons to think that such coordination is currently lacking in the neurosciences of cognition and indicate where changes in these practices appropriate to the natural kinds ideal would be required if achieving this ideal is indeed the goal. However, I suggest that an evaluation of current practices in these research areas is suggestive that discovering natural kinds of cognitive capacities is not the goal. (shrink)